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Azimilide dihydrochloride
CAS No. 149888-94-8
Azimilide dihydrochloride( NE-10064 dihydrochloride )
Catalog No. M12083 CAS No. 149888-94-8
A class ΙΙΙ antiarrhythmic agent that blocks hERG channel; blocks HERG channel at 0.1 and 1 Hz with IC50s of 1.4 uM and 5.2 uM respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 39 | In Stock |
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| 10MG | 55 | In Stock |
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| 25MG | 122 | In Stock |
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| 50MG | 237 | In Stock |
|
| 100MG | 448 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAzimilide dihydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionA class ΙΙΙ antiarrhythmic agent that blocks hERG channel; blocks HERG channel at 0.1 and 1 Hz with IC50s of 1.4 uM and 5.2 uM respectively.
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DescriptionA class ΙΙΙ antiarrhythmic agent that blocks hERG channel; blocks HERG channel at 0.1 and 1 Hz with IC50s of 1.4 uM and 5.2 uM respectively; blocks the rapidly activating component of the delayed rectifier, IKr (IC50=0.4 uM), and inhibits IKs (IC50=3 uM); shows anti-arrhythmic effects.Heart Arrhythmia Phase 3 Clinical.
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In Vitro——
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In Vivo——
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SynonymsNE-10064 dihydrochloride
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PathwayCell Cycle/DNA Damage
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TargetPotassium Channel
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RecptorPotassium Channel
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Research AreaCardiovascular Disease
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IndicationHeart Arrhythmia
Chemical Information
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CAS Number149888-94-8
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Formula Weight530.875
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Molecular FormulaC23H30Cl3N5O3
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Purity>98% (HPLC)
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SolubilityDMSO: < 10.4 mg/mL
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SMILESCN1CCN(CC1)CCCCN2C(=O)CN(C2=O)N=CC3=CC=C(O3)C4=CC=C(C=C4)Cl.Cl.Cl
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Chemical Name2,4-Imidazolidinedione, 1-[[[5-(4-chlorophenyl)-2-furanyl]methylene]amino]-3-[4-(4-methyl-1-piperazinyl)butyl]-, hydrochloride (1:2)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Busch AE, et al. Br J Pharmacol. 1998 Jan;123(1):23-30.
2. Fermini B, et al. J Cardiovasc Pharmacol. 1995 Aug;26(2):259-71.
3. Walker BD, et al. Cardiovasc Res. 2000 Oct;48(1):44-58.
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